Military Applications

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The possible use of deadly chemical and biological weapons on civilians and military personnel cannot be ignored. Deadly agents and delivery systems Chemical warfare agents are non-living toxins that are intended to incapacitate or kill a large number of people. They can be delivered in a variety of ways Once an attack begins, rapid detection and confirmation of the agent are the first steps in saving lives.

A likely scenario would be their release into the air by conventional explosives. There are many different available agents with effects ranging from painful blisters to nerve paralysis and ultimately death. Chemical agents are usually in a gaseous form, but are most effective as larger particles.

Biological warfare agents are considered more deadly and more accessible than chemical agents. These agents are living organisms used to spread life-threatening disease. Bacteria and viruses are the most common. Fungi and toxins, which are products of microorganisms, can also be produced to kill or injure. Many of these organisms are spread through other living things, such as people or plants. Air, water, and food could easily be contaminated with relatively small amounts.

Unfortunately, bioterrorism is real. Enemies throughout the world have the means to create devastating weapons using these deadly agents. We can live in fear, or we can prepare our communities. YourMobileLab Biological and Chemical Defense Systems are a critical part of the necessary preparation Specialized chemical and biological containment facilities PRIMARY AND SECONDARY CONTAINMENT FOR BSL-3 OPERATIONS: We provide the primary and secondary containment systems critical for a BSL3 (P3) Mobile Laboratory. Our engineers work with you to design, manufacture and integrate all of the primary containment enclosures required for your project (Biological Safety Cabinets: Class II and Class III BSC) as well the secondary containment configuration for the BSL3 /P3 laboratory. Because the laboratory is custom-designed by YourMobileLab, the possibilities for equipment integration to meet specific and diverse challenges are nearly limitless. As your single-source provider, we eliminate the need for numerous subcontractors Advanced HVAC Engineering: Critical for any mobile biological safety / containment lab

We do integrate first brands containment equipment. We do understand the complexities of HVAC systems for mobile bio-containment labs.

Capabilities:
• Biosafety Level 2 (BSL-2), aBSL-2, and BSL-3 laboratories; restricted-access research facilities certified for propagation of regulated plant materials and select agent handling.
• Off-site field station for crop growth, pesticide treatment, and toxin treatment analysis.
• Methods to isolate, detect, and assess pathogens, contaminants, and chemicals in food
• Risk mitigation in food production processes, analysis of potential routes of contamination

Mobile Lab Detects Danger—on the Spot

In the aftermath of the September 11, 2001, terror attacks in the United States, many nations have been enacting preventive measures while also improving their ability to respond to a variety of threats, including biological and chemical weapons. For emergency response personnel, the ability to quickly determine the scope and nature of the problem helps contain and control the contamination, thereby protecting public health and saving lives. The rolling lab is equipped with Agilent analytical instrumentation systems: Chemical weapons agent detection and confirmation system, capable of processing air, liquid, solid and soil samples to detect and confirm chemical warfare agents (CWA). It can measure concentrations to the lowest level possible. The recommended configuration includes a gas chromatograph with dual wavelength flame photometric detector and a 5975T LTM (Low Thermal Mass)-MSD system as well as a Thermal Desorption system. Continuous online –air monitoring is also possible. The military has used the instruments to screen, detect, identify, quantify, and confirm agents in weapons defense, monitoring, and demilitarization. The system has proven to be effective in the detection and confirmation of many nerve agents such as sarin gas and VX as well as for blister agents such as mustard gas. The Objective: Detect dangerous chemical and biological warfare agents in the civilian theaters: agents in air, water, soil or food supplies during an emergency situation. Detecting threats to health and the environment such as:

Anthrax Botulism Plague Smallpox Tularemia Viral hemorrhagic fevers Ebola Brucellosis Clostridium perfringens Salmonella Escherichia coli Glanders Melioidosis Psittacosis Q fever Ricin toxin Staphylococcal enterotoxin b Typhus fever Viral encephalitis Vibrio cholerae Cryptosporidium parvum Nipah virus Hantavirus Agent 15 Ammonia Arsenic Benzene Bromobenzylcyanide Chlorine CNB CNC Cyanide Cyanogen chloride Cyclohexyl sarin Diphenylchloroarsine Distilled mustard Ethylene glycol Hydrofluoric acid Hydrogen chloride Hydrogen cyanide Lewisite LSD Mercury Methyldichloroarsine Mustard gas Nitrogen mustard Paraquat Perflurorisobutylene Phosgene Phosphine Ricin Sarin Tabun Thallium VX

Toxic Industrial Compounds System, which can analyze air, water and food samples to identify and quantify organic and inorganic compounds that may pose environmental or health threats. This system includes a gas chromatograph/mass selective detector (GC/MSD), and automated sample prep system that will allow concentration of the sample to detect low concentration levels. (Purge and Trap (P&T), HeadSpace(HS), Solid Phase Microextraction (SPME), online liquid and gas cells.

Biological Weapons Confirmation System, capable of confirming biological weapons (BW) organisms down to the specific strain of bacterium. The integrated instruments are:

The Sherlock® Mycobacteria Identification System (MYCO-LCS), that represents the only commercially-available mycobacterial identification system that analyzes mycolic acids by HPLC. The Sherlock MYCO-LCS represents a rapid, accurate and comprehensive solution for the identification of over 60 mycobacteria and related species in the following genera: Corynebacteria, Dietzia, Gordonia, Nocardia, Rhodococcus and Tsukamurella. The Sherlock MYCO-LCS is currently used in the U.S., Western Europe and China in leading respiratory hospitals and public health labs.

It can analyze for all bacterial BW agents (such as anthrax and plague) as well as a host of other microorganisms. The system uses an Agilent gas chromatograph and MIDI Sherlock® Software. Sherlock® DNA Sequencing Software identifies bacteria, yeast and fungi by rRNA gene sequencing. Sherlock DNA can be used in conjunction with any DNA sequencer and the results can be combined with those from MIDI's two identification systems for polyphasic results.

The Agilent 2100 Bioanalyzer is a microfluidics-based platform for sizing, quantification and quality control of DNA, RNA, proteins and cells on a single platform. Results are delivered within 30-40 minutes in automated, high quality digital data.

Two systems are available: for flow cytometry and electrophoresis applications or for electrophoresis applications only - available at an exciting entry price. Ready-to-use assays and pre-packaged reagent kits Minimal sample consumption (1-4 uL) and lowest exposure to hazardous substances.

Easy to use – load the chip, press "start," the instrument does the rest Digital data for convenient analysis, archiving and storage Contamination-free switch of methods Compliance Services for regulated environments

Besides detecting chemical and biological warfare agents, the lab's equipment -- the gold standard in the industry -- can also test non-weapon chemical spills or environmental contaminants such as PCBs, benzene, gasoline, oil or any type of fuel and phosphorus and sulfur containing compound.

Since 1980s, Agilent in collaboration with its partners and the military has been fielded about 200 such rolling labs, providing an invaluable resource to the military, federal agencies and private laboratories. These mobile labs can provide fast answers about a chemical or biological threat, and the information can be deployed quickly to assist in decision making about the most effective response.

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Rear compartment: Sample preparation

Field personnel submit suspect samples from the outside environment through a small air lock into the rear compartment. This area is where samples are prepared, decontaminated, and transferred to the analysis compartment through another air lock. The class III glovebox and the biological safety cabinet provide the highest level of safety for handling hazardous materials.

The toxic compound analysis system is a fully automated system that includes software containing mass spectral library. The library contains about 212,000 spectra and structures that help identify potentially dangerous organic and inorganic compounds.

Designed for safety. Designed for action. The military mobile laboratory was designed to protect the safety of the analysts as they handle the broadest possible range of chemical and biological unknowns.

The two separate compartments offer a level of safety that allows the researchers to focus on the analysis at hand rather than risks to themselves. In addition to the air locks, each compartment has its own HVAC as well as independent air exchange, air filtration, and pressure settings.

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This creates safe, self-contained research environments.
The mobile lab was created to assist first responders who must identify and assess immediate threats, as well as those who must establish the extent of contamination, define perimeters for public safety and containment purposes, validate decontamination protocols, and provide routine screening and monitoring. It's a robust, reliable solution that enables rapid action for the preservation of public safety.

The chemical warfare analysis system contains an air sampler to collect chemical agents from the air onto solid sorbent cartridges. An optional intake pumping system can be used to safely inject contaminated air from buildings, vehicles, or other outside areas directly into the sampler. The agents are then transferred to the identification and measurement system.

Recommended Analytical instruments:
- The biological warfare analysis system contains the MIDI Sherlock Microbial Identification Software to help identify bacteria based on their unique fatty acid profile. For DNA-based measurements, the complementary Agilent 2100 bioanalyzer can be used following polymerase chain reaction (PCR) amplification.

- The Agilent 2100 Bioanalyzer is a microfluidics-based platform for sizing, quantification and quality control of DNA, RNA, proteins and cells on a single platform. Results are delivered within 30-40 minutes in automated, high quality digital data.
Ready-to-use assays and pre-packaged reagent kits Minimal sample consumption (1-4 uL) and lowest exposure to hazardous substances.
Easy to use – load the chip, press "start," the instrument does the rest Digital data for convenient analysis, archiving and storage Contamination-free switch of methods Compliance Services for regulated environments

Key design features of the military mobile laboratory solution (design example)

• Dual compartments for sample analysis and sample preparation • Global support and warranty coverage for major vehicle components
• Electrical systems designed to comply with local standards, including appropriate voltage and frequency ratings
• Class III glovebox/filtration system
• Class II biological safety cabinet
• Dual air locks
• Fresh air/pressurization system, intake, and exhaust modules with HEPA filter and variable speed blowers – Digital differential pressure meter on exhaust module to create positive or negative pressure in either compartment
• Aircraft-grade track and hold-down system to secure all lab instrumentation and facilitate optional removal of the plate-mounted instrumentation
• Cabinets and drawers under all benches
• Three overhead storage cabinets
• Front and rear stabilizing jacks
• Option of gas- or diesel-powered engine
• Dual roof-mounted air conditioners/heaters
• Solvent storage cabinet sealed with fusible link closure
• Gas cylinder rack
• Two 2.7-cubic-feet refrigerators

Constructed to meet BSL-3 requirements Effective biological containment and the associated Biological Safety Level Rating (BSL) require a combination of specially designed and constructed facilities, the availability and appropriate use of personal protection equipment, and documented compliance with good laboratory practices and techniques.

Although there are currently no formal requirements for a mobile BSL-3 facility, YourMobileLab fabricates for BSL-3 containment based upon extrapolation of the requirements for a fixed BSL-3 laboratory. Some of these design features include:

• Walls, ceilings, and counters are designed to be easy to clean and decontaminate.
• Walls, ceilings, and floors are sealed to prevent air leaks.
• Laboratory access is restricted; windows are sealed shut.
• Laboratory is directly exhausted to the outside through HEPA filters.
• A biological safety cabinet and class III glovebox is available for handling of infectious agents.

Airlocks - Ante-chambers - Pass-through chambers

Airlocks can be any size and equipped with the following:

• Windows
• Sliding trays
• Gloveports
• Interlocks
• HEPA purge filtration (continuous HEPA purge or PLC controlled cycle)
• PLC control (Interlocks and purge cycle)
• Piping and ports for independent decontamination
• Chain of custody port

Through-wall Embeds for BSL-3 Laboratories Through-wall embeds are equipped with seamless bioseals and gaskets to prevent ingress and egress of contaminants. They provide a barrier suitable for BSL3 and P3 applications. Through-wall Embeds Include:Class III BSC through-wall, RTPs (Rapid Transfer Ports), Autoclaves, Airlocks and Chemical dunk tanks

When there is no room for error, technicians rely on YourMobileLab solutions to deliver reliable results, every time.